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Among the participants for whom the primary outcome could be determined, of participants The ordinal analysis showed significantly lower modified Rankin scores with intensive treatment odds ratio for greater disability, 0. Mortality was Nonfatal serious adverse events occurred in In patients with intracerebral hemorrhage, intensive lowering of blood pressure did not result in a significant reduction in the rate of the primary outcome of death or severe disability. An ordinal analysis of modified Rankin scores indicated improved functional outcomes with intensive lowering of blood pressure.

Knee pain and Achilles tendinopathies are the most common complaints among runners. The differences in the running mechanics may play an important role in the pathogenesis of lower limb overuse injuries. However, the effect of a runner's foot strike pattern on the ankle and especially on the knee loading is poorly understood. The purpose of this study was to examine whether runners using a forefoot strike pattern exhibit a different lower limb loading profile than runners who use rearfoot strike pattern.

Soininen H, Nature Genetics Volume 45, Issue 12, Pages — Eleven susceptibility loci for late-onset Alzheimer's disease LOAD were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies GWAS in individuals of European ancestry. In stage 1, we used genotyped and imputed data 7,, SNPs to perform meta-analysis on 4 previously published GWAS data sets consisting of 17, Alzheimer's disease cases and 37, controls.

In stage 2, 11, SNPs were genotyped and tested for association in an independent set of 8, Alzheimer's disease cases and 11, controls. Diarrhoeal diseases cause illness and death among children younger than 5 years in low-income countries. Giugliano, Robert P. Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. Wiffen, Philip J.

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Antiepileptic drugs have been used for treating different types of neuropathic pain, and sometimes fibromyalgia. Our understanding of quality standards in chronic pain trials has improved to include new sources of potential bias. Individual Cochrane reviews using these new standards have assessed individual antiepileptic drugs.

An early review from this group, originally published in , was titled 'Anticonvulsants for acute and chronic pain'. This overview now covers the neuropathic pain aspect of that original review, which was withdrawn in The cardiovascular safety and efficacy of many current antihyperglycemic agents, including saxagliptin, a dipeptidyl peptidase 4 DPP-4 inhibitor, are unclear.

Virtanen, Marianna; Nyberg, Solja T. To determine the association between self reported job insecurity and incident coronary heart disease.

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To report the five-year results of a randomised controlled trial examining the effectiveness of arthroscopic acromioplasty in the treatment of stage II shoulder impingement syndrome. Vimaleswaran, Karani S. Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index BMI and hydroxyvitamin D [25 OH D] using genetic markers as instrumental variables IVs in bi-directional Mendelian randomization MR analysis.

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The aim was to produce a multidisciplinary consensus to determine the current position on the nomenclature, definition, diagnosis, imaging modalities and management of Sportsman's groin SG. New England Journal of Medicine. Although P2Y12 antagonists are effective in patients with non-ST-segment elevation NSTE acute coronary syndromes, the effect of the timing of administration--before or after coronary angiography--is not known. We evaluated the effect of administering the P2Y12 antagonist prasugrel at the time of diagnosis versus administering it after the coronary angiography if percutaneous coronary intervention PCI was indicated.

This article summarizes research from an ecological dynamics program of work on team sports exemplifying how small-sided and conditioned games SSCG can enhance skill acquisition and decision-making processes during training. The data highlighted show how constraints of different SSCG can facilitate emergence of continuous interpersonal coordination tendencies during practice to benefit team game players. Nature Volume , Issue , Pages 67— We performed an integrated genomic, transcriptomic and proteomic characterization of endometrial carcinomas using array- and sequencing-based technologies.

A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.


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European Heart Journal Volume 34, Issue Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length LTL , but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging.

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Biological Psychiatry Volume 73, Issue 7, Pages — Depression is a heritable trait that exists on a continuum of varying severity and duration. Yet, the search for genetic variants associated with depression has had few successes. We exploit the entire continuum of depression to find common variants for depressive symptoms. The present study examined the muscle-tendon interaction of ten international level Kenyan runners. Ultrasonography and kinematics were applied together with EMG recordings of lower limb muscles during repetitive hopping performed at maximal level.

Conversely, the stretching and shortening amplitudes of the tendinous tissues of the medial gastrocnemius MG muscle were significantly smaller in the Kenyans than in controls during the contact phase of hopping. This applied also to the fascicle length changes, which were smaller and more homogeneous among Kenyans.

These limited musculo-tendinous changes resulted in higher maximal hopping height and in larger power despite their reduced body weight. The associated finding of a greater shortening to stretching ratio of the MG tendinous tissues during contact could imply that the Kenyan MG muscle-tendon unit is optimized to favor efficient storage and recoil of elastic energy, while operating at optimal muscle fascicle working range plateau region.


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To assess potentially elevated cardiovascular risk related to new antihyperglycemic drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive evaluation of the cardiovascular safety profile of new antidiabetic therapies. We assessed cardiovascular outcomes with alogliptin, a new inhibitor of dipeptidyl peptidase 4 DPP-4 , as compared with placebo in patients with type 2 diabetes who had had a recent acute coronary syndrome. Ziegler, Anette G. Type 1 diabetes usually has a preclinical phase identified by circulating islet autoantibodies, but the rate of progression to diabetes after seroconversion to islet autoantibodies is uncertain.

Children who undertake more physical activity PA not only have more optimal physical health but also enjoy better mental health. However, the pathways by which PA affects well-being remain unclear. Gouw, Samantha C. For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies inhibitor development.

Niemi-Pynttari, J. Journal of Clinical Psychiatry Volume 74, Issue 1. Despite the clinical importance of substance-induced psychosis SIP , few studies have examined the course of this condition after its acute manifestation. Response to stress can vary greatly between individuals. However, it remains unknown whether perceived impact of stress on health is associated with adverse health outcomes. We examined whether individuals who report that stress adversely affects their health are at increased risk of coronary heart disease CHD compared with those who report that stress has no adverse health impact.

Heikkila, Katriina; Nyberg, Solja T. To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Lindeman, Marjaana; Svedholm, Annika M. We examined with functional magnetic resonance imaging the brain activity of 12 supernatural believers and 11 skeptics who first imagined themselves in critical life situations e. Supernatural believers reported seeing signs of how the situations were going to turn out in the pictures more often than skeptics did.

Viewing the pictures activated the same brain regions among all participants e.

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However, the right IFG, previously associated with cognitive inhibition, was activated more strongly in skeptics than in supernatural believers, and its activation was negatively correlated to sign seeing in both participant groups. We discuss the implications of these findings for research on the universal processes that may underlie supernatural beliefs and the role of cognitive inhibition in explaining individual differences in such beliefs.

Planning for outbreaks of influenza is a high priority public health issue for national governments. Neuraminidase inhibitors NIs are thought to help reduce the symptoms of influenza with several possible mechanisms proposed. NIs have been stockpiled with a view to their widespread use in the event of a pandemic.

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However, the evidence base for this class of agents remains a source of debate. Our confidence in the conclusions of previous versions of this review has been subsequently undermined. Since we have become aware of a large number of unpublished trials of NIs in the management of influenza, this review updates and merges existing reviews in this area. In children with structurally normal hearts, the mechanisms of arrhythmias are usually the same as in the adult patient.

Some arrhythmias are particularly associated with young age and very rarely seen in adult patients. Arrhythmias in structural heart disease may be associated either with the underlying abnormality or result from surgical intervention. Chronic haemodynamic stress of congenital heart disease CHD might create an electrophysiological and anatomic substrate highly favourable for re-entrant arrhythmias. As a general rule, prescription of antiarrhythmic drugs requires a clear diagnosis with electrocardiographic documentation of a given arrhythmia.